The Ventromedial hypothalamic nucleus (VMN) maintains healthy metabolic function through several important roles. Collectively, homeostasis is maintained via intermingled cells within the VMN that raise blood glucose, lower blood glucose, and stimulate energy expenditure when needed. This perspective discusses the defining factors for the VMN cell types that govern distinct functions induced by the VMN, particularly in relation to energy balance and blood glucose levels. Special attention is given to distinct features of VMN cells responsible for these processes. Finally, these topics are reviewed in the context of research funded by the Pathway to Stop Diabetes initiative, highlighting key findings and current unresolved questions for future investigations.
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Perspectives in Diabetes|
October 17 2024
Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes
Jonathan N. Flak
1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
2Lilly Diabetes Research Center, Indiana Biosciences Research Institute, Indianapolis, IN, USA
Correspondence: Jonathan N. Flak, PhD, Indiana Biosciences Research Institute 1210 Waterway Blvd., Ste. 2000, Indianapolis, IN 46022 Phone: 317-983-3315 Fax: 317-983-3350 Email: [email protected]
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Correspondence: Jonathan N. Flak, PhD, Indiana Biosciences Research Institute 1210 Waterway Blvd., Ste. 2000, Indianapolis, IN 46022 Phone: 317-983-3315 Fax: 317-983-3350 Email: [email protected]
Diabetes dbi240011
Article history
Received:
October 03 2024
Accepted:
October 09 2024
PubMed:
39418333
Citation
Jonathan N. Flak; Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes. Diabetes 2024; dbi240011. https://doi.org/10.2337/dbi24-0011
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