The response to a prednisolone glucose tolerance test (PGTT) was investigated in 166 pregnant women, divided into control and diabetes-suspect groups. The diabetes-suspect group consisted of pregnant women with a history of a large infant, a family history of diabetes and/or glycosuria during a previous pregnancy. Positive responses by the criteria of Fajans and Conn occurred in 23 per cent of the control group and 44 per cent of the suspect group. After excluding women with abnormal glucose tolerance tests (GTT), the prevalence of positive responses fell to 15 per cent in the control group and 31 per cent in the suspect group. Thirty patients with normal GTT but positive PGTT during pregnancy were studied at varying intervals after delivery. Half of them reverted to normal PGTT. The increased frequency of positive responses to the PGTT in the suspect group suggests that this presumably more rigorous test of islet reserve may permit recognition of suboptimal islet capacity during pregnancy.
Original Contributions|
November 01 1964
The Prednisolone Glucose Tolerance Test in Pregnancy
G Clayton Kyle, MD;
G Clayton Kyle, MD
George S. Cox Medical Research Institute and the Department of Medicine, University of Pennsylvania
Philadelphia, Pa
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Saliha Yalcin, MD;
Saliha Yalcin, MD
George S. Cox Medical Research Institute and the Department of Medicine, University of Pennsylvania
Philadelphia, Pa
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Richard Drewyer, MD;
Richard Drewyer, MD
George S. Cox Medical Research Institute and the Department of Medicine, University of Pennsylvania
Philadelphia, Pa
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Bruce Carruthers, MD
Bruce Carruthers, MD
George S. Cox Medical Research Institute and the Department of Medicine, University of Pennsylvania
Philadelphia, Pa
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Citation
G Clayton Kyle, Saliha Yalcin, Richard Drewyer, Bruce Carruthers; The Prednisolone Glucose Tolerance Test in Pregnancy. Diabetes 1 November 1964; 13 (6): 572–578. https://doi.org/10.2337/diab.13.6.572
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