The administration of glucose, tolbutamide, ACTH, and glucagon to mice resulted in increase of plasma insulin levels. These increases were all inhibited by the prior administration of aryl-substituted secondary aminoethanols (ASAE). Cyclic 3′,5′ AMP resulted in increased levels of plasma insulin in intact mice, and this stimulatory effect was also inhibited by the aryl-substituted secondary aminoethanols. The locus of the inhibitory effect of these compounds on insulin secretion is discussed.
Original Contributions| May 01 1969
Inhibition of Insulin Secretion by Aryl-substituted Secondary Aminoethanols
Rubin Bressler, M.D.;
Mario Vargas-Cordon, M.D.;
Dr. Brendel is an established investigator of the American Heart Association.
Rubin Bressler, Mario Vargas-Cordon, Klaus Brendel; Inhibition of Insulin Secretion by Aryl-substituted Secondary Aminoethanols. Diabetes 1 May 1969; 18 (5): 262–267. https://doi.org/10.2337/diab.18.5.262
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