Plasma insulin responses to an oral carbohydrate solution were determined in twenty-one normal subjects. Mean insulin values at fasting, 30, 60, and 120 minutes after the carbohydrate load were 13, 109, 90, and 62 μU. per ml., respectively. Twelve subjects retested with 100 gm. of oral glucose had equivalent insulin responses. In nineteen subjects with moderate diabetes, blood glucose and plasma insulin responses to the carbohydrate solution and to 100 gm. of glucose were also equivalent. It is concluded that this form of carbohydrate loading is an effective and reliable challenge to the pancreas.
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