Since some clinical and metabolic features of lipoatrophy suggest increased human growth hormone (HGH) activity, we studied HGH responses in five patients with partial or total lipoatrophy. Two patients with total lipoatrophy had elevated basal levels of HGH of 80 and 25 ng. per milliliter, while two with partial lipoatrophy had abnormally high levels after arginine stimulation. The elevated levels seemed to correlate with the clinical activity of the disease. In one of the patients there was a slowing of the growth rate and a moderate weight gain after long-term chlorpromazine therapy decreased HGH levels; a comparison of the immunoreactive HGH in her serum with that from a normal patient by serial dilution technics suggested that the two were immunologically identical, and chromatographic mobilities were also identical. Oral glucose suppressed elevated HGH in all of the patients. These studies suggest that HGH levels are elevated intermittently in lipoatrophic patients and that the increase may contribute to some features of the disease.

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