Effects of Experimental Diabetes and Genetic Obesity on Regional Blood Flow in the Rat

Blood flow through various tissues of streptozotocin- and alloxan-diabetic and genetically obese rats was compared with that of controls by a radloisotopically labeled microsphere technique. Total cardiac output per unit body weight was unchanged in the diabetic groups but decreased in the obese animais. The proportion of cardiac output received by the kidney and organs of the gastrointestinal tract was increased in the diabetic animals. Tissue hyperplasia appeared to be largely responsible. Blood flow per unit weight was markedly increased in the fat tissue of diabetic rats but was reduced in that of the obese rats, indicating a positive relationship between fat mobilization and blood flow. Blood flow in the hindUmbs, tail, skin, and spleen were all reduced in at least one diabetic group. Most of the changes observed appeared to progress with the duration of diabetes. Possible hormonal and metabolic causes are discussed. Some of the experimental changes observed may form useful models for diabetic vasculopathy.