Rats made diabetic with streptozotocin received a single subcutaneous implant of an insulin polymer pellet that released insulin continuously at approximately 2 U/day. Continuous normoglycemia was achieved for up to 1 mo. Mean glucose level for treated animals was 113 mg/dl as compared with 398 mg/dl for untreated diabetic controls. Diurnal blood glucose values for treated animals ranged from 71 to 116 mg/dl. Polyuria and glycosuria were corrected by the presence of the insulin + polymer. Treated animals gained weight normally and reached a mean weight of 350 g, whereas untreated control animals lost weight, to a mean of 150 g. When insulin + polymer preparations were periodically implanted and removed at 7-day intervals, normoglycemia was only associated with the presence of implants.
Original Contributions|
January 01 1980
One Month of Sustained Release of Insulin from a Polymer Implant
Halimena M Creque;
Halimena M Creque
Department of Surgery, Children's Hospital Medical Center and Harvard Medical School
Boston, Massachusetts
Department of Nutrition and Food Science, Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
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Robert Langer;
Robert Langer
Department of Surgery, Children's Hospital Medical Center and Harvard Medical School
Boston, Massachusetts
Department of Nutrition and Food Science, Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
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Judah Folkman
Judah Folkman
Department of Surgery, Children's Hospital Medical Center and Harvard Medical School
Boston, Massachusetts
Department of Nutrition and Food Science, Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
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Address reprint requests to Judah Folkman, M.D., Children's Hospital Medical Center, 300 Longwood Avenue, Boston, Massachusetts 02115.
Citation
Halimena M Creque, Robert Langer, Judah Folkman; One Month of Sustained Release of Insulin from a Polymer Implant. Diabetes 1 January 1980; 29 (1): 37–40. https://doi.org/10.2337/diab.29.1.37
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