Autonomic neuropathy occurring in sympathetic nerves of the spontaneously diabetic BB rat has been characterized using ultrastructural and morphometric techniques. Paravertebral thoracic ganglion cells, preganglionic myelinated fibers of the white ramus, and postganglionic unmyelinated fibers of the gray ramus communicans were examined in a longitudinal fashion. The main structural abnormality consisted of expanded axons containing a variety of normal and abnormal subcellular structures, so-called dystrophic axonal changes. These increased with duration of diabetes and were found in close proximity to the somata of ganglion cells, suggesting a preganglionic origin. The ganglion cells showed no alteration in perikaryal or nuclear volume but exhibited decreased number of synapses, which correlated with the progressive increase of dystrophic changes. While no qualitative or quantitative abnormalities could be demonstrated in preganglionic myelinated fibers of the white ramus, postganglionic fibers in the gray ramus showed an increased numberof glycogenosomes, axonal sequestration, and reduction in axonal size. The present findings suggest an axonopathy in sympathetic nerves of the diabetic BB rat.
Original Contribution| June 01 1985
Diabetic Autonomic Neuropathy in the BB rat: Ultrastructural and Morphometric Changes in Sympathetic Nerves
Address reprint requests to Dr. A. A. F. Sima, Section of Neuropathology, Department of Pathology, University of Manitoba, Faculty of Medicine, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0W3.
Soroku Yagihashi, Anders A F Sima; Diabetic Autonomic Neuropathy in the BB rat: Ultrastructural and Morphometric Changes in Sympathetic Nerves. Diabetes 1 June 1985; 34 (6): 558–564. https://doi.org/10.2337/diab.34.6.558
Download citation file: