Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-Tlymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of diabetes thereafter. Mice depleted of L3T4+ cells exhibited a reduced incidence and severity of diabetes compared with both untreated and anti-Lyt2.2-treated animals. All mice sustained pancreatic infections, but islet lesions with β-cell degranulation only occurred in control infected and anti-Lyt2.2-treated animals. These data support the conclusion that the induction of diabetes in EMC-infected BALB/c mice is immune mediated and controlled by the L3T4+ T-lymphocyte subpopulation.
Rapid Publications| July 01 1987
Helper-Inducer T-Lymphocytes Mediate Diabetes in EMC-Infected BALB/c By J Mice
Mark K Haynes;
Sally A Huber;
Address correspondence and reprint requests to Dr. John E. Craighead, Chairman, Department of Pathology, University of Vermont, Burlington, VT 05405.
Mark K Haynes, Sally A Huber, John E Craighead; Helper-Inducer T-Lymphocytes Mediate Diabetes in EMC-Infected BALB/c By J Mice. Diabetes 1 July 1987; 36 (7): 877–881. https://doi.org/10.2337/diab.36.7.877
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