Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.
Linkage Analyses of the MODY3 Locus on Chromosome 12q With Late-Onset NIDDM
BMI, body mass index; FH, fasting hyperglycemia; IBD, identical-by-descent; IDDM, insulin-dependent diabetes mellitus; IGT, impaired glucose tolerance; LOD, logarithm of odds; MODY, maturity-onset diabetes of the young; MR, morbid risk; NIDDM, non-insulin-dependent diabetes mellitus; OGTT, oral glucose tolerance test; PCR, polymerase chain reaction; STRP, simple tandem-repeat polymorphism.
Suzanne Lesage, El Habib Hani, Anne Philippi, Martine Vaxillaire, Jörg Hager, Philippe Passa, Florence Demenais, Philippe Froguel, Nathalie Vionnet; Linkage Analyses of the MODY3 Locus on Chromosome 12q With Late-Onset NIDDM. Diabetes 1 October 1995; 44 (10): 1243–1247. https://doi.org/10.2337/diab.44.10.1243
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