A low acute insulin response (AIR) is a predictor of non-insulin-dependent diabetes mellitus (NIDDM) in insulin-resistant Pima Indians. We have initiated a search for regions of the genome linked with the AIR using sib-pair linkage analysis as a first step in identifying genes that are determinants of this phenotype. Eighteen short tandem-repeat polymorphisms from chromosome 1 were genotyped in over 900 Pima Indians and tested for linkage with NIDDM and in a subset of Pima Indians for linkage with AIR. The anonymous DNA marker D1S198 on chromosome 1p was linked with AIR (P = 0.000056) in 175 sib pairs from 60 families, all with normal glucose tolerance, but no linkage was observed between D1S198 and NIDDM (P = 0.44, 996 sib pairs). Additional markers genotyped on chromosome 1 did not show linkage with AIR or NIDDM. This study indicates that a locus on chromosome 1p may be a determinant of the phenotypic variation seen in the AIR.
Evidence for Linkage Between a Region on Chromosome 1p and the Acute Insulin Response in Pima Indians
D Bruce Thompson, Rachel C Janssen, Victoria M Ossowski, Michal Prochazka, William C Knowler, Clifton Bogardus; Evidence for Linkage Between a Region on Chromosome 1p and the Acute Insulin Response in Pima Indians. Diabetes 1 April 1995; 44 (4): 478–481. https://doi.org/10.2337/diab.44.4.478
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