In this report, we examined and compared changes in diabetes technology use and HbA1c levels from data collected in 22,470 participants in the T1DX clinic registry (mean age 26±18 years, duration 14±13 years) between 2016 and 2017 with registry data collected from 25,529 participants (mean age 22±17 years, duration 10±12 years) between 2010 and 2012. There was a moderate increase in insulin pump use across all age groups from 57% in the 2010-12 cohort to 63% in the 2016-17 cohort. In contrast, continuous glucose monitoring (CGM) use rose sharply from 7% to 28%, with the most dramatic increase in the preadolescent and young child groups (4% to 35% for participants <13 years old) (Table). Despite adjustments for differences in age and diabetes duration, mean HbA1c levels increased over time (from 8.2% in 2010-12 to 8.6% in 2016-17), with the greatest rise in participants 13-25 years old (Table). In both cohorts CGM users had lower HbA1c levels than non-users (7.6% in CGM users vs. 8.3% in non-users in 2010-12 and 7.9% in CGM users vs. 8.8% in non-users in 2016-17).

Conclusion: In the T1D Exchange registry, HbA1c levels have increased although HbA1c remains lower in CGM users than non-users.

N.C. Foster: None. K. Miller: None. L. DiMeglio: Advisory Panel; Self; Eli Lilly and Company. Research Support; Self; Dexcom, Inc., Medtronic, Sanofi, Caladrius Biosciences, Inc., Janssen Research & Development, Xeris Pharmaceuticals, Inc., Sanofi. D.M. Maahs: Advisory Panel; Self; Insulet Corporation. Consultant; Self; Abbott. Research Support; Self; Medtronic, Bigfoot Biomedical, Dexcom, Inc., Insulet Corporation, Roche Diabetes Care Health and Digital Solutions. W.V. Tamborlane: Consultant; Self; AstraZeneca, Boehringer Ingelheim GmbH, Eli Lilly and Company, Medtronic MiniMed, Inc., Novo Nordisk Inc., Sanofi, Takeda Pharmaceuticals U.S.A., Inc. R.M. Bergenstal: Research Support; Self; Johnson & Johnson Services, Inc.. Consultant; Self; Johnson & Johnson Services, Inc.. Research Support; Self; Abbott. Advisory Panel; Self; Abbott. Research Support; Self; Becton, Dickinson and Company. Consultant; Self; Becton, Dickinson and Company. Research Support; Self; Boehringer Ingelheim Pharmaceuticals, Inc., AstraZeneca, Takeda Pharmaceuticals U.S.A., Inc., Dexcom, Inc.. Stock/Shareholder; Self; Merck & Co., Inc.. Research Support; Self; Eli Lilly and Company, Sanofi. Advisory Panel; Self; Sanofi, Roche Pharma. Research Support; Self; Novo Nordisk Inc.. Advisory Panel; Self; Novo Nordisk Inc.. Research Support; Self; Medtronic. Consultant; Self; Medtronic. Research Support; Self; Hygieia. Advisory Panel; Self; Hygieia, Glooko, Inc.. Research Support; Self; JAEB Center For Health Research, JDRF, National Institute of Diabetes and Digestive and Kidney Diseases. M.A. Clements: Speaker's Bureau; Self; Medtronic. Advisory Panel; Self; Glooko, Inc. M.R. Rickels: Consultant; Self; Hua Medicine, Xeris Pharmaceuticals, Inc.. E. Smith: None. B.A. Olson: None. R. Beck: Consultant; Self; Eli Lilly and Company. Research Support; Self; Abbott. Consultant; Self; Bigfoot Biomedical. Research Support; Self; Dexcom, Inc.. Consultant; Self; Insulet Corporation. Research Support; Self; Roche Diabetes Care Health and Digital Solutions. Consultant; Self; Merck & Co., Inc., Xeris Pharmaceuticals, Inc..

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