Obesity is associated with deterioration of T2DM and its complications. Although low serum zinc levels are reportedly associated with obesity in nondiabetic people, clinical evidence regarding the association between dietary intake of zinc and obesity in diabetic individuals is sparse. Thus, we aimed to clarify this issue utilizing our nationwide registry of Japanese patients with diabetes. Analyzed were 1891 patients with T2DM (mean age, 62 y; men, 62%) whose data from a food frequency questionnaire were available. Obesity was defined as BMI of ≥25. The associations between obesity and intake of zinc were determined by multivariate regression as well as quintile analyses. Odds ratio (OR) for obesity was 0.74 (0.65, 0.84) per 1 mg increase in zinc intake. Quintile analysis revealed a stepwise decrease in ORs for obesity at higher quintiles. ORs in Q3-Q5 were significant compared to Q1 as the reference (Table). Food groups strongly related to zinc intake among our patients were meats (correlation coefficients, 0.64), fish (0.49), and vegetables (0.47). These results suggest close associations between zinc intake and obesity in patients with T2DM. This information would be clinically applicable for nutrition education.
R. Nedachi: None. K. Fujihara: None. M. Hatta: None. Y. Matsubayashi: None. Y. Takeda: None. D. Ishii: None. C. Horikawa: None. N. Kato: None. H. Maegawa: Research Support; Self; Antares Pharma, Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo Company, Limited, Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Company Limited. Speaker's Bureau; Self; Astellas Pharma Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo Company, Limited, Merck Sharp & Dohme Corp., Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Company Limited. H. Sone: Research Support; Self; Astellas Pharma Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Daiichi Sankyo Company, Limited, Kowa Pharmaceutical Europe Co. Ltd., Kyowa Hakko Kirin Co., Ltd., Novo Nordisk Inc., Ono Pharmaceutical Co., Ltd., Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company Limited, Teijin Pharma Limited.