This study aims to evaluate the association of muscle/fat mass ratio in the first trimester with gestational diabetes mellitus (GDM) in Chinese subjects. A total of 3011 pregnant women were recruited from our hospital, Guangzhou, China, from Jan 2017 to Dec 2017. The muscle/fat mass ratio (< 13+6 weeks’ gestation) and 75-g OGTT (24-28 weeks’ gestation) were measured in each subject. The muscle/fat mass ratio was assessed by bioelectrical impedance analysis. GDM was diagnosed according the IADPSG guideline (2010). All subjects had average age 29 years (interquartile range:27-32 years), mean pregestational body mass index 20.7±2.6kg/m2, muscle/fat mass ratio 2.64±0.65. Five hundred and forty eight subjects (17.9%) were diagnosed as GDM. The prevalence of GDM were 25.9%, 20.4%, 14.1%, and 11.3% among subjects with muscle/fat mass ratio in 1st quartile (≤2.15), 2nd quartile (2.16-2.61), 3rd quartile (2.62-3.08), and 4th quartile(≥3.09), respectively. The prevalence of GDM decreased while muscle/fat mass ratio increased. The area under ROC curve was 0.612 (0.595-0.630) for the muscle/fat mass ratio in predicting GDM (P<0.0001) and the threshold of 2.59 yielded the highest combination of sensitivity (63.2%) and specificity (55.7%). This study suggested the muscle/fat mass ratio in the first trimester may be used as an index to predict GDM in Chinese subjects.


P. Li: None. S. Lin: None. J. Fan: None. L. Zeng: None.


Science and Technology Planning Project of Guangdong Province (2017A020215026); Medical Scientific Research Foundation of Guangdong Province (A2017314)

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at