Objective: Investigating the correlation between serum uric acid (SUA) level in adult males and their fasting blood glucose (FBG) level in the time of 1.5 years.

Methods: Retrospective analysis based on two physical examinations including laboratory tests held at the Beijing Hospital during the period from 2014 to 2018, on 2337 adult males who work on non-physical jobs. Mean age was 61.6±13.3 at the first exam and 63.1±13.3 at the second exam. The two exams were held in the same season with an interval of 1-2 years (average 1.5). Results were collected from questionnaire, physical exams, and laboratory tests including levels of SUA, FBG, Hemoglobin Subunit Alpha 1, total cholesterol, triglycerides, LDL-c, HDL-c, creatinine, etc. During the first exam, no diabetes mellitus, gout, hepatic and renal insufficiency or malignant tumor was found, and all participants showed FBG < 7.0 mmol/L. Data were divided into 4 groups based on SUA levels obtained from the two exams. Group 1 (296 participants, 12.7%): SUA ≥ 420umol/L in both exams. Group 2 (458 participants, 19.6%): SUA ≥ 420umol/L in one exam while 240 ≤ SUA < 420umol/L in the other one. Group 3 (1479 participants, 63.3%): 240 ≤ SUA < 420umol/L in both exams. Group 4 (104 participants, 4.4%): SUA<240umol/L.

Results:1. A total of 136 participants (5.8%) showed FBG ≥ 7.0 mmol/L at the second exam, among which 29 (9.8%) belong to group 1, 40 (8.7%) belong to group 2, 65 (4.4%) belong to group 3, and 2 (1.9%) belong to group 4 (X2 24.000,P 0.000). 2. Risk analysis: Compared to group 4, the risk of individuals having FBG≥7.0mmol/L was 5.539 (95%CI 1.298-23.637) for group 1, 4.880 (95%CI 1.160-20.527) for group 2, and 2.344 (95%CI 0.566-9.712) for group 3.

Conclusions: The Hyperuricemia in adult males, especially those with Chronic Hyperuricemia, is correlated to the increase of FBG in the time of 1.5 years. Hyperuricemia is potentially a predictor of FBG increase in adult males, and clinical diagnosis of diabetes is required for those having FBG≥7.0mmol/L.

Disclosure

Y. Wang: None.

© 2020 by the American Diabetes Association
2020
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.