1079-P: Maternal Gestational Diabetes and Childhood Hyperlipidemia

Very few studies have assessed the impact of maternal gestational diabetes mellitus (GDM) on lipid profiles in the offspring in China. We aim to compare the lipid profile between children exposed to maternal GDM and those not exposed, and assess association between maternal GDM and offspring’s dyslipidemia risk. We recruited 1144 mother-child pairs (572 GDM and 572 non-GDM women matched by their offspring’s age and sex). We used general linear models to compare mean values of different lipid profiles among children born to mothers with and without GDM. Logistic regression models were used to assess associations of GDM with abnormal lipid profiles in offspring. After adjustment for maternal and children’s characteristics, children born to mothers with GDM had lower mean values of high-density-lipoprotein (HDL) cholesterol (1.40±0.01 vs. 1.50±0.01; P <0.05) and higher mean levels of triglycerides/HDL cholesterol ratio (0.37±0.01 vs. 0.35±0.01; P <0.05) in comparison with their counterparts born to mothers without GDM. Multivariate-adjusted odds ratios among children exposed to mothers with GDM compared with the counterparts were 2.07 (95% confidence interval [CI 1.13-3.79]) for low HDL cholesterol and 1.36 (95% CI 1.01-1.82) for high triglycerides/HDL cholesterol ratio, respectively. Exposure to GDM mothers was an independent risk factor for the abnormal lipid profile among children, which can emerge as early as in the preschool period.