The Aim: to identify key genes involved in angiogenic response and influenced by enhanced glycemic variability (GV) in diabetes.
Methods: Text-mining of Medline/Pubmed abstracts, reconstruction and analysis of gene networks related to GV and angiogenesis was performed by ANDSystem (www-bionet.sscc.ru/and/cell/). Genes associated with both hyperglycemia and hypoglycemia were attributed to be GV-related. Compounds targeting the identified genes were found using the TTD database (db.idrblab.net/ttd/).
Results: The set of genes implicated in angiogenesis that are up- or down-regulated by both hyperglycemia and hyperglycemia and compounds targeting and regulating these genes are summarized in the Table.
Conclusions: The obtained results support the hypothesis that detrimental effect of enhanced GV in diabetes could be realized by up- or down-regulation of the genes involved in angiogenic response. The role of the identified genes and compounds influencing their activity in the development of diabetic vascular complications requires experimental testing.
O. V. Saik: None. V. Klimontov: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Sanofi, Research Support; Self; Boehringer Ingelheim International GmbH, Speaker’s Bureau; Self; AstraZeneca, Medtronic.
Russian Science Foundation (20-15-00057)