Introduction: Obesity predisposes to Type 2 Diabetes, thus risk stratification among the nondiabetes people with obesity is important. Insulin-like Growth Factor-1 (IGF1) and Insulin-like Growth Factor Binding Proteins (IGFBPs), which modulate metabolism, may predict diabetes in such high-risk adults.
Methods: In this case cohort analysis nested within the GeneSTAR study, 40 incident diabetes cases and 40 in a random cohort sample with a BMI ≥ 30 kg/m2 at baseline (38% males, 50% African Americans, age range 22-69 years) were followed for incident diabetes during a follow up of ≥10 years. Sampling-weighted logistic regression assessed the relationship between baseline IGF/IGFBP biomarkers measured by ELISA and diabetes risk.
Results: Lower levels of IGF1, IGFBP1, IGFBP2, IGFBP3 and IGFBP6 predicted 10-year diabetes incidence adjusting for demographic factors (Table, Model 1). This association remained statistically significant for IGFBP2, IGFBP3 and IGFBP6 after adjusting for fasting glucose at baseline (Model 2).
Conclusions: IGF/IGFBP complex proteins may serve as early indicators for diabetes risk in people with obesity without current diabetes beyond fasting glucose levels. Future studies should investigate the functional role of the IGF/IGFBP system in glucose metabolism and diabetes prevention.
P. Maurya: None. L. Yanek: None. J. Yang: None. A.D. Everett: Advisory Panel; Merck & Co., Inc. L. Becker: None. D. Vaidya: None.
National Institutes of Health (HL092165 and HL099747)
