We evaluated the efficacy of guideline-directed intervention and diabetes education for lifestyle modification in liver health in T2DM on active treatment (n=229). We performed a comparative analysis of baseline and follow-up FIB-4 and liver stiffness measures. The FIB-4 scores slightly decreased on average from baseline (mean 2.478) to the last assessment (mean 2.362), with a wider variation in the data at the last measure (increased standard deviation). Median values remained consistent at 2. Liver stiffness measures (kPa) decreased on average from 14.59 to 13.7 with a consistent range of variability. The median decreased from 10.9 to 8.9, suggesting an overall improvement in liver stiffness. BMI values remained relatively stable from baseline (mean 30.03) to follow-up (mean 30.08), with a slight increase in variation and a higher maximum value at the last measurement. The study showed a marginal but positive trend in liver health, with a slight decrease in FIB-4 scores and a more notable improvement in liver stiffness, indicating potential therapeutic benefit. Despite these improvements, BMI values remained stable, indicating that the positive liver outcomes may not be directly associated with changes in body weight. Further investigation may be required to understand the underlying factors contributing to liver health improvements.
D. Padhye: None.
