1814-LB: Hypertriglyceridemic-Waist Phenotype Is Associated with Diabetic Foot Ulcer in Chinese Patients with Type 2 Diabetes

It is still unclear whether the hypertriglyceridemic-waist (HTGW) phenotype is related to increased risk of diabetic foot ulcer (DFU) in Chinese patients with type 2 diabetes. A total of 2651 consecutive in-patients with type 2 diabetes (mean age 56±11 years, 58% women), with a mean duration of diabetes of 9.3 years, were included to identify the relationship. The diagnosis of HTGW was made if TG≧1.70mmol/L plus waist circumference≧90cm for men (or ≧80cm for women) according to the IDF criteria for the metabolic syndrome. The study population was then divided into HTGW subgroup and Non-HTGW subgroup. DFU was diagnosed according to guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019). Logistic regression analysis was applied to relate HTGW phenotype to DFU. The prevalence of DFU was 9.3% and 4.2% respectively in patients with and without HTGW. Compared with participants who had no HTGW, those with the HTGW phenotype had higher levels of systolic blood pressure (139.2 mmHg vs. 132.7 mmHg, p<0.05), fasting plasma glucose (9.1 mmol/L vs. 8.5 mmol/L, p<0.05), HbA1c [73 mmol/mol (8.83%) vs. 63 mmol/mol (7.95%), p<0.05], apolipoprotein B ( 0.95 g/L vs. 0.89 g/L, p<0.05), C-reactive protein (8.23 mg/L vs. 4.92 mg/L, p<0.05), and TNF-α ( 26.46 pg/ml vs. 16.80 pg/ml, p<0.05) but lower levels of apolipoprotein A1 (1.21g/L vs. 1.33g/L, p<0.05). The hypertriglyceridemic-waist phenotype was associated with DFU (OR 1.33, 95% CI 1.03-2.71), after adjusting for age, sex, duration of diabetes, body mass index, smoking, HbA1c, apolipoprotein B and C-reactive protein. Among patients with type 2 diabetes, simultaneous measurement of waist circumference and triglycerides could be used as an inexpensive and simple approach to identify individuals with increased risk of DFU.