Objective: The purpose of this study is to investigate the clinical characteristics and high-risk factors of insulinoma combined with secondary adrenal cortical insufficiency.
Methods: This was a retrospective study including 44 surgically confirmed insulinoma patients and 16 diabetes patients with hypoglycemia. IBM SPSS Statistic 27 was used for statistical analysis.
Results: The proportion of low morning cortisol levels was significantly higher in insulinoma patients than in diabetes patients with hypoglycemia. Compared to diabetes patients with hypoglycemia, insulinoma patients had lower blood glucose levels during hypoglycemia. Additionally, serum cortisol levels in the morning and midnight were lower in insulinoma patients, with a significantly greater decrease in morning serum cortisol levels (Fig.1). In insulinoma patients group, both the insulin release index(IRI) >1.2 group and the insulin levels >38.6uIu/ml group had larger tumor diameters than the IRI <0.3 group and the insulin levels 18.8-38.6uIu/ml group, respectively. The tumor diameters ≥1cm group had lower morning serum cortisol and ACTH than the tumor diameters<1cm group.
Conclusion: Our study suggests that larger tumors may be associated with secondary adrenal insufficiency in insulinoma patients, thereby increasing perioperative risks of insulinoma patients.
X. Wang: None. L. Yu: None. Y. Chen: None. X.J. Hui: None.
