630-P: Vitamin D Deficiency and Its Association with Clinical Parameters in Type 2 Diabetes—Findings from a Cross- Sectional Study in India

Introduction & Objective: The interplay between vitamin D deficiency and type 2 diabetes (T2D) has gained significant attention, with studies indicating that vitamin D deficiency is a potential risk factor for T2D. This study aimed to explore the association between vitamin D deficiency and key clinical parameters in individuals diagnosed with T2D.

Methods: A cross-sectional study was conducted on 2787 T2D-diagnosed patients enrolled in a one-year online lifestyle intervention program at the Freedom from Diabetes Clinic, India, from January to September 2023. The intervention comprised a customized plant-based diet, exercise, stress management, and medical support. Demographic, clinical, and anthropometric data were collected. Serum vitamin D levels were assessed using standardized assays; levels <20 ng/ml indicated deficiency.

Results: The mean age of the study population was 49±10 years (62% male), and 43% had vitamin D deficiency. There was a statistically significant relationship between poor glycemic control (HbA1c>7%) and vitamin D deficiency (p<0.05). Vitamin D deficiency was associated with increased levels of LDL-C, triglycerides, and total cholesterol, and decreased HDL-C levels (p<0.05). Vitamin D deficiency was significantly higher in patients with elevated hsCRP levels (47%) than in those with normal hsCRP levels (42%) (p<0.05), highlighting the role of vitamin D in inflammatory processes. Additionally, vitamin D deficiency was associated with shorter disease duration (<6 years), younger age (<40 years), and male sex (p<0.05).

Conclusion: Our study highlights significant links between vitamin D deficiency and metabolic markers, notably poor glycemic control, lipid abnormalities, and inflammation. Further investigations to determine the causal relationships between these factors and develop targeted interventions for managing vitamin D deficiency in individuals with type 2 diabetes are warranted.