Introduction: Nighttime burdens of T1D include responding to CGM-generated alerts and delivering manual boluses which interrupt sleep. First-generation automated insulin delivery (AID) systems without autocorrection (e.g., MM670G/770G) have improved overnight glycemic outcomes, but sleep interruptions may still be common. The ability of the MM780G with frequent (every 5-min) autocorrections to decrease nighttime burden, versus the MM770G, was evaluated.
Methods: Nighttime (12AM-6AM) glycemic control, alarms/alerts, and insulin delivery were evaluated in 8019 U.S. MM780G system users (≥7 years) who transitioned from the MM770G and had ≥14 nights on both systems, in addition to those who used recommended settings (RS, a glucose target of 100mg/dL with active insulin time of 2 hours for 95% of the time).
Results: In all MM780G users and those who used RS, alerts decreased 45% and 55%, respectively (Table). Nights with manual boluses decreased to 3.8% and 2.1% and uninterrupted sleep increased by 30 and 36 minutes per night, respectively, compared to the MM770G. All MM780G users and those using RS received 16.4% and 18.2% of their overnight insulin as autocorrections.
Conclusion: MM780G system users have fewer overnight sleep interruptions and better glycemic control due to frequent autocorrections.
J. Shin: None. Z. Dai: Employee; Medtronic. N. Sathiyanathan: None. R.A. Vigersky: Employee; Medtronic. J. McVean: Employee; Medtronic.
