In 101 diabetic adults without complications we determined before and during long-term treatment with sulfonylurea derivatives the serum protein content, electrophoretic serum composition, alkaline serum phosphatase, bromsulphalein retention, in serum, and in the twenty-four-hour urine free α-amino nitrogen and free α-amino acids were measured. The oxidative function of the liver was examined by loading with 2 gm. of methionine. The electrophoretic serum protein composition was only altered in sulfonylurea failure. After successful long-term treatment no changes in serum protein composition, alkaline serum phosphatase and bromsulphalein retention were found; however, the hyperaminoacidemia and hyperamino-aciduria decreased to normal values. The cause of this effect is probably an augmented production of insulin, which improves the oxidative deamination of amino acids in the liver.
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Original Contributions| January 01 1964
The Effect of Long-term Treatment with Sulfonylurea Derivatives on Protein Metabolism in Diabetes Mellitus
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Dieter Müting; The Effect of Long-term Treatment with Sulfonylurea Derivatives on Protein Metabolism in Diabetes Mellitus. Diabetes 1 January 1964; 13 (1): 14–21. https://doi.org/10.2337/diab.13.1.14
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