The Enzymatic Nature of Phospholipid Synthesis in Normal Rabbit and Human Aorta: Results of In Vitro Studies

Evidence has been presented to show that phospholipids are synthesized by supernatants of homogenates of rabbit and human aorta when palmitate-l-C-14, or linoleate-l-C-14, are used. The synthetic process is enzymatic in nature; it depends on temperature, pH, and the presence of various cofactors. These requirements are not unlike those of cellfree liver preparations, which also synthesize phospholipids.