The change in concentration of blood glucose in hypoglycemic diabetic boys and girls after treatment with glucagon (1 or 2 mg. given subcutaneously) or glucose (20 gm. orally) was determined. Following glucagon, at both dose levels, the concentration of blood glucose was increased after five minutes, was within the physiologic range by fifteen minutes and did not return to hypoglycemic levels during one hour. Symptoms of hypoglycemia were relieved in ten minutes in each instance. The time course of change in the concentration of blood glucose was identical at both dose levels of glucagon. With glucose orally a similar response was noted during the first fifteen minutes but the concentration of blood glucose was lower at thirty and at sixty minutes. It is concluded that the hyperglycemic response to glucagon in hypoglycemic diabetic boys and girls was identical with a 1 or 2 mg. dose.
Treatment of Insulin Hypoglycemia in Diabetic Campers: A Comparison of Glucagon (1 and 2 mg.) and Glucose
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Joseph C Shipp, Harry K Delcher, John F Munroe; Treatment of Insulin Hypoglycemia in Diabetic Campers: A Comparison of Glucagon (1 and 2 mg.) and Glucose. Diabetes 1 November 1964; 13 (6): 645–648. https://doi.org/10.2337/diab.13.6.645
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