Comparison of Pancreatic and Steroid Diabetes in Respect to Tumor Growth and Glycosuria

Sexually mature male rats were made severely diabetic by either pancreatectomy or daily injection of large doses of cortisone acetate. One half of the animals were then made host to Walker Carcinoma 256. The tumor suppressed the glycosuria in all of the animals, but the effect was greater in steroid diabetes than in pancreatic diabetes. Diabetogenic doses of cortisone inhibited the growth of tumor to a greater extent than did pancreatic diabetes. The depancreatized tumor host is partially resistant to the diabetogenic action of cortisone.