Nine patients with diabetes mellitus and three normal controls were treated for one week with hydrochlorothiazide (150 mg. per day), and certain effects on carbohydrate metabolism were observed. Evidence presented in this study confirms the thiazide-induced carbohydrate intolerance. Tests of insulin reserve (serum ILA response to glucose), response to insulin, insulin binding, urinary steroid excretion, serum potassium, serum nonesterified fatty acids, and serum amylase failed to reveal any abnormality related to the carbohydrate intolerance. There was reduction of the whole blood glutathione levels in six of seven subjects. DIABETES 14:132–36, March 1965.

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