Recent experiments have shown that commercial insulin produces an increase in short circuit current across the isolated short-circuited frog skin.1 This in vitro phenomenon was observed only in the presence of Ca++ and Mg++ which suggested that these ions were necessary for the action of insulin in such an experimental system. The present study utilizing intact mice was designed to determine the effect of added Ca++ and Mg++ in an in vivo system.
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Copyright © 1965 by the American Diabetes Association
1965
