Studies Concerning the Hyperglycemic Effects of Diazoxide and Its Mode of Action

Diazoxide in doses of 200 mg. per kg. was administered orally to normal, adrenalectomized, hypophysectomized, and partially pancreatectomized rats. The hyperglycemic effect was studied five hours after drug administration.

It was observed that: (1) Diazoxide produced no hyperglycemia in adrenalectomized animals. (2) Diazoxide hyperglycemia was lower in hypophysectomized animals, disappearing entirely one month after hypophysectomy. (3) Diazoxide hyperglycemia in partially pancreatectomized animals diminished with prolonged drug administration over a period of twenty-two days.

These experiments in partially pancreatectomized rats are being continued.