Pancreatic A-Cell Tumor Associated with Severe Diabetes Mellitus

This paper describes a case of pancreatic A-cell tumor associated with severe diabetes mellitus and high levels of serum extractable glucagon-like activity. The tumor was detected clinically about six months before diabetes mellitus became manifest.

It is suggested that the development of diabetes mellitus in this case may have been influenced by the tumor and by the elevated serum glucagon-like activity.