In sixteen patients, thirteen examinations were carried out after intravenous administration of 1 gm. of tolbutamide, including measurements of insulin clearance and glucose TmG before and after administration. Furthermore, four examinations were performed with administration of 1 gm. of tolbutamide daily over periods from fourteen days to 160 days. No alterations in insulin clearance were found. The changes in glucose TMGpresented fairly large individual variations and increases between 20 and 30 per cent were observed in a few patients. An average increase of 9.1 per cent was found after intravenous administration and of 4.8 per cent after oral administration. These variations are not significant.

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