Ten diabetic patients, secondary failures to sulfonylureas, seven of whom were receiving maximal doses of tolbutamide and three of chlorpropamide, were concurrently given L-leucine, as tablets, in a daily dosage of 12 gm. for four to eight weeks. Good diabetic control, with most blood glucose values below 130 mg. per 100 ml., was achieved in three; a good response, as indicated by a fall in blood glucose values of 20 per cent or more, occurred in eight; two patients did not respond. Of four patients receiving thiazide, which might have contributed to their secondary failure, three responded. Reversal of osmotic diuresis and symptoms of nocturia occurred in five patients. No untoward effects of any significance were noted. Adjunctive use of L-leucine for better diabetic control in patients who have become refractory to sulfonylureas, or are receiving thiazides, is suggested.
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March 01 1966
L-Leucine in Secondary Sulfonylurea Failure
Harold Rifkin, M.D.;
Harold Rifkin, M.D.
Medical Division, Montefiore Hospital and Medical Center
Bronx, New York
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Stephen Podolsky, M.D.;
Stephen Podolsky, M.D.
Medical Division, Montefiore Hospital and Medical Center
Bronx, New York
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Herbert Ross, M.D.;
Herbert Ross, M.D.
Medical Division, Montefiore Hospital and Medical Center
Bronx, New York
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Emil G Conason, M.D.;
Emil G Conason, M.D.
Medical Division, Montefiore Hospital and Medical Center
Bronx, New York
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Sylvia Most, PhD
Sylvia Most, PhD
Medical Division, Montefiore Hospital and Medical Center
Bronx, New York
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Citation
Harold Rifkin, Stephen Podolsky, Herbert Ross, Emil G Conason, Sylvia Most; L-Leucine in Secondary Sulfonylurea Failure. Diabetes 1 March 1966; 15 (3): 222–224. https://doi.org/10.2337/diab.15.3.222
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