Stimulation of Insulin Secretion by Pancreozymin

The peripheral injection of pancreozymin in dogs at doses greater than one-eighth dog unit/kg, has been shown to produce an abrupt rise in portal vein plasma insulin. A dose of 0.5 U./kg. proved to be a more potent stimulus of insulin secretion than 0.5 gm./kg. of glucose. A combination of pancreozymin and glucose produced more pronounced hyperinsulinemia than the sum of the two given separately. Repeated injections of pancreozymin appear to have a decreasing stimulatory effect. Pancreozymin produced a decrease in free fatty acids but did not lower plasma glucose.