White rats made subdiabetic by the administration of small doses of alloxan were stressed by a buzzer and electric shock program for one and one-half hours every week day for four months. An increase in blood sugar with frequent glycosuria was observed immediately after the stress periods. Nonstressed subdiabetic control rats showed glycosuria only rarely. The average fasting blood sugar was 79.25 mg. before stress and 127.87 mg. per 100 ml. after stress, an average increase of 48.6 mg. per 100 ml. above the preshock level. This increase was more than twice as great as that found in normal (nonalloxanized) rats after similar stress. The diabetic indices, calculated from glucose tolerance data, however, were not increased by the stress regimen; they actually decreased, becoming for the most part normal during the months of stress. After termination of stress the diabetic indices of the experimental animals again increased to subdiabetic levels and were then similar to those of the nonstressed alloxanized controls.

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