Insulin isolated from normal and diabetic pancreas was isolated and injected intraperitoneally into rats together with C-14 glucose. Measurement of C-14 incorporation into the diaphragm showed a significantly lesser biologic activity for diabetic insulin.

These results are in accord with earlier work on the resistance of diabetic insulin to insulinase and on the inheritance of diabetes in terms of the abnormal insulin. The possibilities for a mutation site in the insulin molecule are discussed in relation to known molecular variations.

This content is only available via PDF.