Intraperitoneal administration of ATE obtained from pooled epididymal fat pads produced hypoglycemia in adrenalectomized rats. Injection of extracts from rat brain, liver and muscle did not affect the blood glucose levels of the adrenalectomized animals. With high ATE concentrations, a progressive decline in blood sugar was observed and most of the animals died from hypoglycemia ten to thirteen hours after intraperitoneal injection.Identical concentration of ATE did not affect the blood glucose levels in intact rats.

In some adrenal ectomized rats injected with ATE (100 mg.) a progressive bound insulin fall was detected, but no significant change in free insulin was evidenced.

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