Infantile idiopathic hypoglycemia appears to be an early manifestation of an early manifestation of an inherited metabolic defect that leads to diabetes mellitus. Eight children with this form of hypoglycemia were studied for the presence of synalbumir insulin antagonism. All had diabetes in one or both parenta families. Two of the children had normal antagonist level. before and after they developed chemical diabetes. A thirt child was tested twice after she was found to have chemica diabetes, and on each occasion had normal antagonist levels. Rather than a causa sine qua non for the develop ment of diabetes, or a constant feature of the disorder, ex cess synalbumin insulin antagonism appears to be a variable expression of a more fundamental metabolic abnormality ir essential diabetes mellitus.

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