Two critically ill patients are described in whom the intravenous administration of Dilantin produced marked alterations in plasma glucose and blood pressure. The first patient, a nondiabetic with chronic lung disease received a total of 1.8 gm. Dilantin over a 48-hr, period for status epilepticus. Plasma glucose increased from normal to 1,200 mg./100 ml. and his seizures became focal in nature. The second patient, a mildly diabetic male, experienced renal shut-down and multiple arrythmias after a myocardial infarct. Three hours after a single intravenous injection of 200 mg. Dilantin, plasma glucose rose from 400 mg. to 1,260 mg./100 ml. and proved relatively resistant to insulin. Intravenous administration of 25 mg. Dilantin per kg. in four dogs promptly induced marked hyperglycemia and hypotension.
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Original Contribution|
February 01 1969
Hyperglycemic, Nonketotic Coma Following Administration of Dilantin (Diphenylhydantoin)
E Marshall Goldberg, M.D.;
E Marshall Goldberg, M.D.
Hurley Hospital
Flint, Michigan
Department of Medicine, Michigan State College of Human Medicine
East Lansing, Michigan
Department of Medicine, University of Michigan Medical Center
Ann Arbor, Michigan
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Shafeek S Sanbar, M.D.
Shafeek S Sanbar, M.D.
Hurley Hospital
Flint, Michigan
Department of Medicine, Michigan State College of Human Medicine
East Lansing, Michigan
Department of Medicine, University of Michigan Medical Center
Ann Arbor, Michigan
Search for other works by this author on:
Reprint requests to Hurley Hospital, Flint, Michigan 48503 (Dr. Goldberg).
Citation
E Marshall Goldberg, Shafeek S Sanbar; Hyperglycemic, Nonketotic Coma Following Administration of Dilantin (Diphenylhydantoin). Diabetes 1 February 1969; 18 (2): 101–106. https://doi.org/10.2337/diab.18.2.101
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