The administration of glucose, tolbutamide, ACTH, and glucagon to mice resulted in increase of plasma insulin levels. These increases were all inhibited by the prior administration of aryl-substituted secondary aminoethanols (ASAE). Cyclic 3′,5′ AMP resulted in increased levels of plasma insulin in intact mice, and this stimulatory effect was also inhibited by the aryl-substituted secondary aminoethanols. The locus of the inhibitory effect of these compounds on insulin secretion is discussed.

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