In a seventeen-year-old woman with a strong family history of diabetes mellitus, changes in glucose tolerance and plasma insulin response to oral glucose were followed from the early stage of diabetes through exacerbations and remissions of the disease. At the first glucose tolerance test which revealed normal fasting and elevated postprandial blood sugar values, the plasma insulin level at thirty minutes was subnormal but the peak level, which was delayed to ninety minutes, was above normal. During the exacerbation when fasting blood sugar values were elevated, insulin response was markedly diminished. In the stage of improvement following treatment with oral drugs and insulin, plasma insulin response to oral glucose improved remarkably. During the course of subsequent exacerbation and improvement, the degree of plasma insulin response changed in a similar inverse manner with the blood sugar level. The observations suggest that the diminished insulinsecretory capacity in severe diabetes does not always indicate irreversible damage of insulin releasing mechanisms.

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