Insulin Response in Pancreatectomized Dogs Treated with Oxytetracycline

Treatment with dxytetracycline seems to prolong and intensify the activity of insulin administered to pancreatectomized dogs. Oxytetracycline-treated dogs can be kept normoglycemic with small doses of insulin, have nondiabetic glucose tolerance, and exhibit the impaired hyperglycemic and cardiac responses to epinephrine of normal animals treated with insulin.