A negative urinary glucose oxidase test in the presence of glucbsuria may occur in patients with alcaptonuria or the carcinoid syndrome. It may also be noted after ingestion of aspirin or L-dopa. The responsible agents are potent reducing metabolites such as gentisic acid, homogentisic acid, or 5-hydroxyindole acetic acid. These agents produce the misleading reaction by keeping the indicator dye o-tolidine in its reduced form. In the presence of such reducing agents the tests for glucosuria should be carried out either with Tes-Tape or by modifying the manufacturer's instructions and only partially immersing the Clinistix strip.
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Original Contributions| May 01 1970
Inhibition of Glucose Oxidase Paper Tests by Reducing Metabolites
Jerome M Feldman, M.D.;
William N Kelley, M.D.;
Jerome M Feldman, William N Kelley, Harold E Lebovitz; Inhibition of Glucose Oxidase Paper Tests by Reducing Metabolites. Diabetes 1 May 1970; 19 (5): 337–343. https://doi.org/10.2337/diab.19.5.337
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