Somatotrophin Action in Fatty Liver and Ketonemia in Pancreatectomized-Sympathectomized Dogs

Somatotrophin was injected (1 mg./kg./day) in pancreatectomized-sympathectomized and pancreatectomized-hypophysectomized dogs for two days. The results were compared with those in noninjected pancreatectomized, pancreatectomized-sympathectomized and pancreatectomized-hypophysectomized animals. It was found that (l)-hypophysectomy and sympathectomy decreased ketonemia and lipolysis [lower levels of plasma free fatty acids (FFA)] in diabetic pancreatectomized dogs and (2) somatotrophin increased plasma ketone bodies, FFA and total lipids in pancreatectomized-sympathectomized (those deprived of the sympathetic chains) and in pancreatectomized-hypophysectomized dogs.