The effect of tolbutamide on portal and peripheral vein immunoreactive insulin concentrations in man was assessed and compared with that of a glucose stimulus. The portal vein IRI responses to both stimuli were similar. The ratios of peripheral vein to portal vein insulin response (area under the curve) following tolbutamide administration were the same or lower than that following a glucose infusion.
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Copyright © 1971 by the American Diabetes Association
1971