Improvement in Both Insulin Sensitivity and Release Following Diabetic Coma

Serial estimations of both plasma insulin following intravenous glucose and the hypoglycemic potency of intravenous insulin were performed on two patients following hyperosmolar coma and in one after diabetic ketoacidosis.

In all, plasma insulin and insulin sensitivity were initially low and both increased markedly over several months. Concurrently the clinical control of diabetes was possible by either oral agents or diet alone.