1. Reactive hypoglycemia (for the purpose of this evaluation: blood glucose levels of 59 mg. per 100 ml. or less at the second, third, fourth or fifth hours of an oral glucose tolerance test) occurred in about 17 per cent of a group of 285 adult females participating in a survey.

2. This degree of reactive hypoglycemia occurred more often in the younger members (twenty to forty-five years of age), i.e., in 19 per cent of those with body weight less than 146 lbs. and in 31 per cent of those whose weight was above this range. Hypoglycemia was distinctly less frequent in the older nonoverweight females (2 per cent) and in the older obese group (11 per cent).

3. The lesser frequency of this degree of reactive hypoglycemia in the older nonobese and obese groups is attributable to higher fasting levels of glucose and to greater increments in blood glucose levels following upon an oral glucose load and not to any decrease in the usual increments in insulin.

4. In the two younger groups (twenty to forty-five years of age and either less than 146 lbs. or 146 lbs. or more in weight), those with reactive hypoglycemia as defined above had lower fasting blood glucose levels. This fact alone accounted for the subsequent occurrence of hypoglycemia. This conclusion is supported by the finding that the responses of those with and those without the stated degree of hypoglycemiaare Indistinguishable in terms of increments in blood glueose increments in insulin, and in the rations of the two.

5. Our data permit the generalization that blood glucose levels between 59 and 41 mg. per 100 ml. in the later hours of an oral glucose tolerance test are so common in young individuals, nonobese and obese, that this must be taken into account in any evaluation of so-called functional or reactive hypoglycemia in persons of this age. This degree of hypoglycemia is much less frequent in persons above forty-five of age.

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