Perinatal maturation of the pancreatic beta cells was studied in the rat. Insulin synthesis proceeded rapidly be tween the twentieth gestational day and the third postnatal day. The insulin concentration in the pancreas and the amount of insulin available per gram of body weight reached a maximum sixty hours after birth and then decreased slowly toward the values observed in the adult rat. The pancreatic beta cells became responsive to glucose and to tolbutamide during the twenty-third day after fertilization, This phenomenon seemed to be related to the gestational age and not to act of birth or to feeding, although feeding appeared to increase the insulinogenic response to glucose.
Effects of Gestational Age, Birth and Feeding on the Insulinogenic Response to Glucose and Tolbutamide by Fetal and Newborn Rat Pancreas
The present address of Dr. F. Sodoyez-Goffaux is Department of Pediatrics, University of Liège, Liège, Belgium.
Dr. J.-C. Sodoyez is Charge de Recherches of the Fonds National de la Recherche Scientifique, Bruxelles, Belgium. His present address is Department of Medicine, University of Liège, Liège, Belgium.
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Francoise Sodoyez-Goffaux, Jean-Claude Sodoyez, Piero P Foá; Effects of Gestational Age, Birth and Feeding on the Insulinogenic Response to Glucose and Tolbutamide by Fetal and Newborn Rat Pancreas. Diabetes 1 September 1971; 20 (9): 586–591. https://doi.org/10.2337/diab.20.9.586
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