Plasma insulin levels were measured in rabbits in response to the administration of leucine and of arginine. Suppression of the amino-acid-induced insulin secretion by pretreatment with mannoheptulose and with 2-deoxy-D-glucose was attempted. The insulin response to leucine was suppressed to about 50 per cent of control values by both mannoheptulose and 2-deoxy-D-glucose. The response to arginine was not significantly altered by 2-deoxy-D-glucose hut was suppressed to 27 per cent of control values by mannoheptulose. The data suggest that (1) substances interfering with glycolysis can suppress amino-acid-induced insulin release and (2) arginine and leucine cause insulin secretion by different mechanisms.

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