Pregnancy in the diabetic is at high risk. Recent efforts to improve perinatal mortality have principally been directed at establishing a laboratory assessment which could be used in the management of the diabetic pregnancy. Data on the hormones—estrogen, progesterone, human placental lactogen (HPL) and human chorionic gonadotropin (HCG) and on the enzymes—heat-stable alkaline phosphatase (HSAP) and diamine oxidase (DAO) are briefly reviewed for uncomplicated and for diabetic pregnancies.

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